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UBIQUITIN-PROTEIN LIGASE COMPLEXES
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DeCS
Descriptor
Inglés
:
Ubiquitin-Protein Ligase Complexes
Descriptor
Español
:
Complejos de Ubiquitina-Proteína Ligasa
Descriptor
Portugués
:
Complexos Ubiquitina-Proteína Ligase
Sinónimos
Inglés
:
Complexes, Ubiquitin-Protein Ligase
Ligase Complexes, Ubiquitin-Protein
Ubiquitin Protein Ligase Complexes
Categoría:
D08.811.464.938
Definición
Inglés
:
Complexes of
enzymes
that catalyze the covalent attachment of
UBIQUITIN
to other
proteins
by forming a peptide bond between the C-terminal
GLYCINE
of
UBIQUITIN
and the alpha-amino groups of
LYSINE
residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal
proteins
. The complex of
enzymes
can be broken down into three components that involve activation of
ubiquitin
(
UBIQUITIN-ACTIVATING ENZYMES
), conjugation of
ubiquitin
to the ligase complex (
UBIQUITIN-CONJUGATING ENZYMES
), and
ligation
of
ubiquitin
to the substrate protein (
UBIQUITIN-PROTEIN LIGASES
).
Nota de Indización
Inglés
:
UBIQUITIN-PROTEIN LIGASES
is also available
Nota Histórica
Inglés
:
2004
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
38180
Identificador Único:
D043743
Ocurrencia en la BVS
:
Similar:
DeCS